Caries vaccine: current reality or remote future?

نویسندگان

  • A. C. B. Silva
  • D. R. Silva
  • I. G. Silva
  • P. A. P. Oliveira
  • G. G. Agripino
  • S. A. Marinho
چکیده

Dental caries remains a public health problem in developing countries requiring effective strategies to combat this disease. Caries vaccines showed promising results in experimental studies; however, it remains far the effective use in humans due to political-economic and ethical issues. The purpose of this chapter is to review the literature on the main research projects aimed at developing caries vaccines. The following topics will be covered: virulence and cariogenicity of Streptococcus mutans, caries vaccine, animal models for testing caries vaccines, caries vaccine types, and replacement or substitution therapy and future prospects.

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تاریخ انتشار 2013